Regulation of temperature habituation through neuron and intestine in nematode <i>Caenorhabditis elegans</i>

DOI Web Site 14 References
  • KUHARA Atsushi
    Graduate School of Natural Science, Konan University, & Institute for Integrative Neurobiology
  • UJISAWA Tomoyo
    Graduate School of Natural Science, Konan University, & Institute for Integrative Neurobiology
  • OHTA Akane
    Graduate School of Natural Science, Konan University, & Institute for Integrative Neurobiology

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  • 線虫<i>Caenorhabditis elegans </i>の温度適応を制御する神経と腸を介した情報処理
  • 線虫Caenorhabditis elegansの温度適応を制御する神経と腸を介した情報処理
  • センチュウ Caenorhabditis elegans ノ オンド テキオウ オ セイギョ スル シンケイ ト チョウ オ カイシタ ジョウホウ ショリ

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Temperature is an essential environmental stimulus with affecting animal’s biochemistry. Animals can respond to temperature changes through altered physiology. Yet, how animals habituate to ambient temperature is poorly known. Nematode C. elegans stores temperature experience that induces temperature habituation-linked cold tolerance. We show here that a light and pheromone-sensing neuron (ASJ) regulates cold habituation through insulin signaling. Cold habituation is abnormal in a mutant impairing trimetic G protein signaling in ASJ. Ca2+ imaging and genetic analysis indicate that ASJ neuron acts as temperature sensing neuron. Insulin molecules released from synapses of ASJ is received by the intestine and neurons, which regulates gene expression for cold habituation. Essential molecular physiological systems are conserved throughout human to C. elegans, and the systems found in this study can therefore provide a useful model for studying temperature habituation.

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