Optogenetic analysis of neural circuits in zebrafish

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  • 光遺伝学によるゼブラフィッシュ神経回路機能の解析
  • ヒカリ イデンガク ニ ヨル ゼブラフィッシュ シンケイ カイロ キノウ ノ カイセキ

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Abstract

Optogenetics is a new experimental technique that allows us to manipulate specified neuronal activity with light. In recent years, this method has been applied to uncover causal relationships between activity in specified neural circuits and behavior. Zebrafish is one of the most useful animals for applying optogenetics. Since the larval zebrafish is small and translucent, non-invasive manipulation with light is possible. The optogenetic tools can be easily applied to specific neurons in this genetic model organism. In zebrafish, electrophysiological or imaging approach can be easily combined with optogenetic analysis, which strongly helps us to understand the function of the neural circuits. Furthermore, zebrafish is a simple model organism to analyze neural circuits in vertebrates, because it has an archetypal vertebrate body plan and exhibit a wide range of simple behaviors. Here I review recent literature in which optogenetic tools were successfully applied to the analysis of zebrafish neural circuits. I also introduce our optogenetic analysis of the locomotor circuits in the hindbrain which play indispensable roles in generating zebrafish swimming.

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