Effect of Adriamycin Entrapped in Sulfatide-Containing Liposomes on Colon Tumor Cells Metastasized.

DOI オープンアクセス
  • NAKAHARA Hideya
    Department of Surgery, Nagoya University School of Medicine
  • YAMAUCHI Masaji
    Department of Surgery, Nagoya University School of Medicine Present address: Tokai Chuo Hospital
  • TAKAGI Hiroshi
    Department of Surgery, Nagoya University School of Medicine
  • YAGI Kunio
    Institute of Applied Biochemistry, Yagi Memorial Park

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説明

Antineoplastic effect of adriamycin entrapped in sulfatidecontaining liposomes on colon tumor cells metastasized to the liver and preventive effect of the liposome-entrapped adriamycin on liver metastasis were studied by use of an in vivo murine model for liver metastasis made by portal injection of cells of colon 26, a murine colon cancer cell line. The levels of adriamycin in the liver at 24 and 72h after intravenous administration of the drug entrapped in sulfatide-containing liposomes were 68.2±8.7 and 47.5±12.0 nmol/g liver tissue, respectively. In the case of free adriamycin, those levels were 3.1±1.0 and 2.4±1.0nmol/g tissue. These results indicate that upon entrapment of adriamycin in the liposomes, a higher level of the drug was maintained in the liver for a longer time than the free drug. Administration of 6mg/kg of adriamycin entrapped in liposomes at 7 days after the injection of colon 26 cells brought about a significant reduction in the number of colonies on the liver surface counted at 14 days after cell injection compared with the free drug (p<0.05). The pretreatment with adriamycin entrapped in liposomes resulted in the absence of colonies in 4 of 6 mice and significantly prolonged their survival time (p<0.05). These results indicate that liposomal adriamycin is effective in the treatment of liver metastasis.

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詳細情報 詳細情報について

  • CRID
    1390282679647883776
  • NII論文ID
    130003670296
  • DOI
    10.3164/jcbn.16.115
  • ISSN
    18805086
    09120009
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
    • OpenAIRE
  • 抄録ライセンスフラグ
    使用不可

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