Control of Platelet Adhesion and Cell Attachment to He+ Ion Irradiated Collagen for the Development of Small Diameter Vascular Graft Material

DOI 15 References

Bibliographic Information

Other Title
  • 血小板粘着，細胞接着性を制御したコラーゲンの血管修復材への応用

Search this article

Description

Our previous study indicated that He+-irradiated collagen grafts with a fluence of 1×1014 ions/cm2 have excellent blood compatible properties. Also, the collagen grafts demonstrated a high antithrombogenicity and graft patency. 150 keV-He+ irradiated collagen with a fluence of 1×1014 ions/cm2 simultaneously has the 2 properties of antithrombogenicity and cell attachment. In vitro platelet adhesion and plasma protein adsorption were evaluated to investigate the mechanisms of antithrombogenicity of these surfaces. Antithrombogenicity of the He+-irradiated collagen was caused by the reduction of the plasma protein adsorption such as the von Willebrand factor by ion beam irradiation. <br> He+-irradiated collagen surfaces will be useful for the substrates of small-diameter vascular grafts.<br>

Journal

References(15)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top