PUFA Content and Effect of Dietary Intake of .GAMMA.-Linolenic Acid-Rich Oil on Profiles of n-6, n-3 Metabolites in Plasma of Children with Atopic Eczema.

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The content and composition of polyunsaturated fatty acids (PUFA) in the plasma total lipid fraction of 51 Japanese children (age 3-10) with atopic eczema and those in age-matched healthy controls (n=30) were studied by a simplified method for fatty acid analysis with gas-liquid chromatography (GLC). The PUFA content of the plasma total lipid (p<0.001) and the amounts of linoleic (18:2 n-6, p<0.01), dihomo-γ-linolenic (20:3 n-6, p<0.05), and arachidonic (20:4 n-6, p<0.05) acids were significantly lower in the atopic patients than in the control subjects. When atopic patients were fed candy-type jellies containing γ-linolenic acid-rich oil (180mg/day as the amount of γ-linolenic acid) for 8 weeks, the lower levels of PUFA significantly rose to those of the healthy controls. No side effects were observed in the PUFA profiles, n-6 and n-3 long-chain metabolites, or in clinical evaluations. The results indicate that the dietary intake of γ-linolenic acid-rich oil is an efficient additional therapy for young patients with atopic eczema who have altered states of fatty acid metabolism.

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Details 詳細情報について

  • CRID
    1390282679648224128
  • NII Article ID
    130003670357
  • DOI
    10.3164/jcbn.19.183
  • COI
    1:CAS:528:DyaK28XjsFWisL8%3D
  • ISSN
    18805086
    09120009
    http://id.crossref.org/issn/09120009
  • Text Lang
    en
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
    • OpenAIRE
  • Abstract License Flag
    Disallowed

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