Clinical Significance of Selenium Level in Chronic Pancreatitis

UEHARA Soichiro, HONJO Kyosuke, HIRANO Fuminori, SAKAI Norio, HIRAYAMA Akio, JIN Kazuo

doi:10.3164/jcbn.5.201

Clinical Significance of Selenium Level in Chronic Pancreatitis

DOI

UEHARA Soichiro

Department of Internal Medicine, Tonan Hospital
HONJO Kyosuke

Department of Internal Medicine, Tonan Hospital
HIRANO Fuminori

Department of Internal Medicine, Tonan Hospital
SAKAI Norio

Department of Internal Medicine, Tonan Hospital
HIRAYAMA Akio

Department of Internal Medicine, Tonan Hospital
JIN Kazuo

Hokkaido Institute of Public Health

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説明

Blood selenium concentrations were found to be significantly lower in patients with chronic pancreatitis than in normal controls. The activity of the selenoenzyme erythrocyte glutathione peroxidase had a significant positive correlation with selenium concentration and it was also significantly lower in patients with the disease. These findings suggest that selenium deficiency and reduced glutathione peroxidase activity are associated with the elevation of lipid peroxides in chronic pancreatitis.