Cytoprotective Effect of .ALPHA.-Tocopherol against Parietal Cell Vacuolar Degeneration Induced by Omeprazole in Guinea Pig Gastric Mucosa.

DOI オープンアクセス
  • OHARA Tadashi
    Department of Internal Gastroenterology, Sendai Shakai Hoken Hospital
  • SAITOH Michiya
    The Third Department of Internal Medicine, Tohoku University School of Medicine
  • KATAKURA Toshiki
    The Third Department of Internal Medicine, Tohoku University School of Medicine
  • SUZUKI Hitoshi
    The Third Department of Internal Medicine, Tohoku University School of Medicine
  • SASAKI Shigeru
    The Third Department of Internal Medicine, Tohoku University School of Medicine

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説明

Vacuolation of gastric parietal cells was studied in guinea pigs chronically given high doses of omeprazole (OPZ) with or without the antioxidant α-tocopherol. Animals were divided into two groups: one group was treated with OPZ alone (20mg/kg); and the other, with OPZ (20mg/kg) plus α-tocopherol (50mg/kg). After 4 weeks of administration, the histological changes in the parietal cells and lipid peroxide formation in the gastric mucosa were assessed. The α-tocopherol concentration of the gastric mucosa after α-tocopherol administration was also measured. Parietal cell vacuolation was completely inhibited in the group given OPZ and α-tocopherol concomitantly, and lipid peroxidation levels were also significantly lower than in the group given OPZ alone. The α-tocopherol concentration of the gastric mucosa was increased significantly by α-tocopherol. These findings suggest that lipid peroxidation by OPZ is involved in parietal cell vacuolar degeneration when high doses of OPZ are administered for long periods.

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詳細情報 詳細情報について

  • CRID
    1390282679649323264
  • NII論文ID
    130003670319
  • DOI
    10.3164/jcbn.17.171
  • COI
    1:CAS:528:DyaK2MXjvFWnt7o%3D
  • ISSN
    18805086
    09120009
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
    • OpenAIRE
  • 抄録ライセンスフラグ
    使用不可

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