Increase of transient lower esophageal sphincter relaxation associated with cascade stomach
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- Kawada Akiyo
- Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
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- Kusano Motoyasu
- Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital
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- Hosaka Hiroko
- Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
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- Kuribayashi Shiko
- Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
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- Shimoyama Yasuyuki
- Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
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- Kawamura Osamu
- Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital
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- Akiyama Junichi
- Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
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- Yamada Masanobu
- Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
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- Akuzawa Masako
- Hidaka Hospital
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説明
<p>We previously reported that cascade stomach was associated with reflux symptoms and esophagitis. Delayed gastric emptying has been believed to initiate transient lower esophageal sphincter relaxation (TLESR). We hypothesized that cascade stomach may be associated with frequent TLESR with delayed gastric emptying. Eleven subjects with cascade stomach and 11 subjects without cascade stomach were enrolled. Postprandial gastroesophageal manometry and gastric emptying using a continuous 13C breath system were measured simultaneously after a liquid test meal. TLESR events were counted in early period (0–60 min), late period (60–120 min), and total monitoring period. Three parameters of gastric emptying were calculated: the half emptying time, lag time, and gastric emptying coefficient. The median frequency of TLESR events in the cascade stomach and non-cascade stomach groups was 6.0 (median), 4.6 (interquartile range) vs 5.0, 3.0 in the early period, 5.0, 3.2 vs 3.0, 1.8 in the late period, and 10.0, 6.2 vs 8.0, 5.0 in the total monitoring period. TLESR events were significantly more frequent in the cascade stomach group during the late and total monitoring periods. In contrast, gastric emptying parameters showed no significant differences between the two groups. We concluded that TLESR events were significantly more frequent in persons with cascade stomach without delayed gastric emptying.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｎｕｔｒｉｔｉｏｎ
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Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｎｕｔｒｉｔｉｏｎ 60 (3), 211-215, 2017
一般社団法人 日本酸化ストレス学会