Increasing Oxidative Stress with Progressive Hyperlipidemia in Human: Relation between Malondialdehyde and Atherogenic Index
-
- Yang Rui-Li
- State Key Lab of Food Science and Technology, Jiangnan University
-
- Shi Yong-Hui
- State Key Lab of Food Science and Technology, Jiangnan University
-
- Hao Gang
- State Key Lab of Food Science and Technology, Jiangnan University
-
- Li Wu
- State Key Lab of Food Science and Technology, Jiangnan University
-
- Le Guo-Wei
- State Key Lab of Food Science and Technology, Jiangnan University
この論文をさがす
説明
The aim of this study was to examine whether malondialdehyde (MDA) formation, a marker of oxidant stress, is altered in different stages of development of hyperlipidemia and whether it correlates with atherogenic index (AI), an important risk factor of atherosclerosis. Commercial kits were used to measure the levels of lipid profile and antioxidant status in the serum of 15 hyperlipidemic patients and 30 age and sex-matched normolipidemic subjects. The normolipidemic subjects were divided into lower and higher lipid groups according to their blood lipid level. The activities of superoxide dismutase and glutathione peroxidase decreased in higher lipid group compared with lower lipid group, and were even lower in hyperlipidemic subjects. An increase in the levels of MDA, triglycerides, total cholesterol and LDL-C concentration were observed in higher lipid group, and even significantly increased in hyperlipidemic patients. A significant progressive decline in HDL-C concentration was found during hyperlipidemia evolution. There was a positive correlation between MDA and AI (r = 0.61, p<0.05). These data indicate that oxidative stress is an early event in the evolution of hyperlipidemia, and appropriate support for enhancing antioxidant supply in higher lipid subjects may help prevent the course of the disease.<br>
収録刊行物
-
- Journal of Clinical Biochemistry and Nutrition
-
Journal of Clinical Biochemistry and Nutrition 43 (3), 154-158, 2008
一般社団法人 日本酸化ストレス学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679649654656
-
- NII論文ID
- 130004879152
-
- COI
- 1:STN:280:DC%2BD1cjkslynug%3D%3D
-
- ISSN
- 18805086
- 09120009
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可