Serum levels of bone Gla-protein

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Other Title
  • 血液透析患者の血清bone Gla-protein
  • Assessment of its clinical value as an index of bone metabolism in hemodialysis patients
  • 骨代謝の指標としての意義について

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Description

Predictive values of serum bone Gla-protein (BGP) and alkaline phosphatase (ALP) for bone histology were evaluated in 39 hemodialysis patients. All patients underwent bone biopsies, and serum levels of BGP and ALP were measured at the time of biopsy.<br>Osteoblastic activity correlated well with serum BGP, and somewhat less well with serum ALP. Serum BGP showed a highly significant correlation with the tetracycline labeling rate, corrected mineral appositional rate, and bone formation rate. These histomorphometric parameters were significantly correlated, but to a lesser degree, with serum ALP. Osteoclastic bone resorption was also correlated with serum BGP, but only marginally with serum ALP. Furthermore, serum BGP showed a significant negative correlation with the corrected mineralization lag time, bone formation period, the [resorption+reversal] period, and remodeling period. In contrast, weak correlations, of none at all, were found between serum ALP and these histomorphometric parameters.<br>The data indicate that serum BGP is a good marker for evaluating bone remodeling (bone resorption, formation and mineralization) in hemodialysis patients, and serum ALP mainly reflects bone formation activity by osteoblasts. Serum BGP seems to be a better index of bone turnover than serum ALP in hemodialysis patients.

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Details 詳細情報について

  • CRID
    1390282679650928256
  • NII Article ID
    130003720820
  • DOI
    10.4009/jsdt1985.21.861
  • ISSN
    18846211
    09115889
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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