Serum level of tumor markers in patients with chronic renal failure

DOI
  • Yokoyama Keitaro
    Second Department of Internal Medicine, Jikei University School of Medicine
  • Kawaguchi Yoshindo
    Second Department of Internal Medicine, Jikei University School of Medicine
  • Yamamoto Yasuhiro
    Second Department of Internal Medicine, Jikei University School of Medicine
  • Morita Takashi
    Second Department of Internal Medicine, Jikei University School of Medicine
  • Momose Mituo
    Second Department of Internal Medicine, Jikei University School of Medicine
  • Ogawa Aiichiro
    Second Department of Internal Medicine, Jikei University School of Medicine
  • Wakabayashi Yoshinori
    Second Department of Internal Medicine, Jikei University School of Medicine
  • Nakayama Masaki
    Second Department of Internal Medicine, Jikei University School of Medicine
  • Sakai Soichi
    Second Department of Internal Medicine, Jikei University School of Medicine
  • Sakai Osamu
    Second Department of Internal Medicine, Jikei University School of Medicine

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Other Title
  • 慢性腎不全患者における腫瘍マーカー (TM) の基準値 -特に治療法による差異について-

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Description

The incidence of malignancy in patients with chronic renal failure has increased recently in accordance with the prolongation of dialysis.<br>Routine serological screening for malignancy has been applied in dialysis patients, but abnormal values have not been defined. Therefore values in patients with chronic renal failure not complicated with malignancy should be determined for the clinical application of tumor markers.<br>Seventy-four patients (17 with chronic renal failure not on dialysis, 30 on hemodialysis and 27 on CAPD) participated in this study.<br>CEA, TPA, AFP, EL1, CA125, CA19-9 and γ Sm were determined by radioimmunoassay or enzymeimmunoassay and compared with values obtained from 81 healthy controls.<br>CEA, TPA, AFP and EL1 were significantly higher in patients with chronic renal failure. No patients with chronic renal failure were positive for CA125. But CEA, TPA and AFP were significantly higher in patients on hemodialysis than in those not recieving dialysis, However there was no significant difference between hemodialysis and CAPD.<br>The radioimmunoassay applied to tumor markers in this study was not infuluenced by uremic substance, The reason for the higher values might be delayed removal from the blood stream due to impaired renal function.

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