The association between atherosclerosis and plasma homocysteine
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- NAKAZATO Mio
- Department of Island and Community Medicine
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- TAKAMURA Noboru
- Department of Radiation Epidemiology
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- KADOTA Koichiro
- Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences
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- YAMASAKI Hironori
- Health Center, Nagasaki University
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- MUKAE Hiroshi
- Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences
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- KUSANO Yosuke
- Human Service and Community Development, Nagasaki Wesleyan University
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- NAKASHIMA Kenichiro
- Department of Clinical Pharmacy
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- OZONO Yoshiyuki
- Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences
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- AOYAGI Kiyoshi
- Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences
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- KOHNO Shigeru
- Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences
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- MAEDA Takahiro
- Department of Island and Community Medicine
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説明
Although hyperhomocysteinemia is an important and independent risk factor for vascular disease, the relationship between plasma homocysteine concentration (Hcy) and subclinical atherosclerosis in the general population remains controversial. We screened 1,845 participants who resided on Japanese remote islands and in mainland. Hcy and clinical values were measured, and methylenetetrahydrofolate reductase gene C677T polymorphism (C677T/MTHFR), which is an important genetic factor for regulating Hcy, was analyzed. Carotid intima-media thickness (CIMT) and the cardio ankle vascular index (CAVI) were measured to clinically evaluate subclinical atherosclerosis. CAVI had statistically significant association with Hcy (regression coefficient 0.3159, p=0.025), but CIMT was not. Hcy had statistically significant association with age, systolic blood pressure, high-density lipoprotein cholesterol, creatinine, C677T/MTHFR, smoking status and alcohol intake. Although C677T/MTHFR was not different among residing areas, Hcy was significantly higher on small islands than in other areas even after adjustment for confounding factors. We found the statistically significant association between Hcy and CAVI in the general population residing on Japanese remote islands, and significant differences in Hcy among residing areas, suggesting strong influence by acquired factors as well as genetic factors.
収録刊行物
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- Acta Medica Nagasakiensia
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Acta Medica Nagasakiensia 55 (2), 47-54, 2011
長崎大学医学部
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詳細情報 詳細情報について
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- CRID
- 1390282679651706240
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- NII論文ID
- 130004451001
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- COI
- 1:CAS:528:DC%2BC3MXht1ymsbzP
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- ISSN
- 00016055
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可