透析患者における腸内フローラの改菩および腐敗産物の産生抑制に対する乳酸菌製剤の効果
書誌事項
- タイトル別名
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- Prevention of accumulation of uremic toxin precursors in the feces by oral administration of a lactic acid bacteria preparation to uremic patients undergoing hemodialysis.
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説明
Plasma levels of phenol, p-cresol and indican are markedly elevated in uremic patients, but it is impossible to efficiently reduce them by hemodialysis (HD). Such uremic toxins are produced in the intestine as bacterial putrefactive metabolites.<br>Analysis of fecal microflora revealed an imbalance in its composition characterized by the overgrowth of aerobic bacteria during HD. Balance was restored by oral administration of the lactic acid bacteria preparation Lolon® S. Oral feeding of this lactic acid bacteria compound also reduced levels of putrefactive substances in the stools.<br>These findings demonstrated that oral feeding of lactic acid bacteria to uremic patients is effective in reducing the accumulation of uremic toxins by reducing bacterial production through the correction of imbalances in intestinal microflora.<br>Based on the results of this study, we propose the introduction of “probiotics”, such as the lactic acid bacteria employed in this study, as a means of reducing uremic toxins.
収録刊行物
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- 日本透析医学会雑誌
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日本透析医学会雑誌 29 (4), 285-289, 1996
一般社団法人 日本透析医学会
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詳細情報 詳細情報について
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- CRID
- 1390282679651762944
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- NII論文ID
- 130003721385
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- ISSN
- 1883082X
- 13403451
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
