酢酸透析と重炭酸透析におけるCa・骨代謝の比較検討

DOI

書誌事項

タイトル別名
  • Studies of Ca-bone metabolism using acetate or bicarbonate dialysate in hemodialysis patients

この論文をさがす

抄録

A study was performed in order to compare Ca metabolism in acetate dialysate (Ca++ 3.0mEq/l) and bicarbonate dialysate (Ca++ 3.0mEq/l) in hemodialysis patiente.<br>In bicarbonate dialysate, plasma levels were Ca++ 2.2±0.3mEq/l, Mg 2.8±0.4mg/dl and Al 45±26μg/l, which were lower than in acetate dialysate, while the level of P, 6.1±5.4mg/dl, was higher. However, C-PTH a significant increase during hemodialysis.<br>In patients who had begun hemodialysis treatment using acetatl or bicarbormte dialysate 6 months previously, a significant decrease in C-PTH was found in bicarbonate dialysate: C-PTH level in bicarbonate dialysate was 42.3±3.4% of the initial value, and 85.5±38.7% in acetate dialysate. On the other hand, there were no differences in the changes of Ca and P between bicarbonate dialysate and acetate dialysate.<br>Bone mineral contents in bicarbonate dialysate were lower than in acetate dialysate after 2 years: decreases were found in MCI (MD method) in 4/12 cases (33.3%), ΣGS/D in 9/12 cases (75.0%) and BMC/BW in 6/12 cases (50.0%).<br>The decrease in C-PTH was more marked in bicarbonate dialysate than in acetate dialysate, implying that bicarbonate supresses PTH secretion.<br>Low serum PTH, low turnover bone, severely increased acidosis, and a decrease of bone mineral contents may frequently occur in bicarbonate dialysate.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ