Acetate-free biofiltration was effective for the control of lactic acidosis in hemodialysis patient with mitochondrial disease

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  • 乳酸アシドーシスを繰り返すミトコンドリア遺伝子異常透析患者にアセテートフリーバイオフィルトレーション（ＡＦＢ）を施行した１例
  • 症例報告 乳酸アシドーシスを繰り返すミトコンドリア遺伝子異常透析患者にアセテートフリーバイオフィルトレーション(AFB)を施行した1例
  • ショウレイ ホウコク ニュウサン アシドーシス オ クリカエス ミトコンドリア イデンシ イジョウ トウセキ カンジャ ニ アセテートフリー バイオフィルトレーション AFB オ シコウシタ 1レイ

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Abstract

Mitochondrial disease patients develop lactic acidosis due to the accumulation of lactate and pyruvate. Here, we report a diabetic hemodialysis patient with mitochondrial disease accompanied by deafness, hypertrophic cardiomyopathy, congestive heart failure and lactic acidosis, that occurred frequently during maintenance hemodialysis. Hypotension and severe fatigue on dialysis treatment caused a decrease in the quality of life (QOL), and were not improved by hemodiafiltration (HDF). However, these symptoms were moderately improved after changing the dialysis method to acetate-free biofiltration (AFB). The lactate/pyruvate ratio (i.e, lactic acidosis index) decreased to nearly the normal range after AFB.

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