Effects of albumin leakage on glycoalbumin levels in hemodialysis patients

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  • ダイアライザーのアルブミン漏出量の違いがグリコアルブミン値に及ぼす影響

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The effects of differential albumin leakage from the dialyzer on glycoalbumin (GA) levels were investigated. Forty-six chronic hemodialysis patients used either dialyzer PS [Polysulfone, removal rate (β2-MG)=0.7, albumin leakage=2.85(g/session)] or dialyzer MRC [Modified reproductive cellulose, removal rate (β2-MG)=0.3, albumin leakage=1.7(g/session)]. Patients were classified by glucose tolerance and allotted dialyzer into 4 groups: nonDM-PS (n=13), nonDM-MRC (n=12), DM-PS (n=11), DM-MRC (n=10). GA levels were measured at 4 points: before use of the dialyzer, 2 months, 6 months, and 12 months after the use of the dialyzer.<br>Changes in GA levels exhibited significant differences depending on whether dialyzer PS or MRC was used. In the nonDM-PS and DM-PS groups, GA values decreased significantly 2 months after beginning to use dialyzer PS, then returned to control levels after 6 months. In the nonDM-MRC and DM-MRC groups, there was no significant change in GA levels throughout the year.<br>These results indicate that increased albumin leakage from the dialyzer may cause acute reduction of GA levels. However, GA levels appear to be modified by other effects over the long term.

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