血液透析施行時におけるメシル酸ナファモスタットの先発品と後発品の比較検討

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タイトル別名
  • A Comparison of brand-name and generic versions of the anticoagulant, nafamostat mesilate, for hemodialysis
  • ケツエキ トウセキ シコウジ ニ オケル メシルサン ナファモスタット ノ センパツヒン ト コウハツヒン ノ ヒカク ケントウ

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Nafamostat mesilate has been widely used as an anticoagulant in hemodialysis patients with hemorrhagic diathesis. We compared brand-name and generic versions of the anticoagulant, nafamostat mesilate, with regard to the quantity of precipitate and the effect as an anticoagulant in twelve patients. By the cross-over method, there was no significant difference in the effects as an anticoagulant between the two versions of the drug. However, the quantity of precipitate was larger for the generic version than for the brand-name drug. The difference in the quantity of precipitate might be due to differences in additives or the level of impurities. When introducing the generic medicines, it must be considered that these versions might not be completely identical to the brand-name drug.

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