The induction of sister chromatid exchanges by benzo(a)pyrene in cultured peripheral blood lymphocytes from lung cancer patients and from healthy individuals with high or low risks of cancer.

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  • Dosaka Hirotoshi
    The 1st Department of Medicine, School of Medicine, Hokkaido University

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  • 肺癌患者，癌発症高危険群健康人および低危険群健康人におけるベンツピレン誘発姉妹染色分体交換の研究

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The inducibility of sister chromatid exchanges (SCEs) by benzo [a] pyrene (BP) was studied in cultured peripheral blood lymphocytes of untreated lung cancer patients and healthy individuals with high or low risk for developing cancer, each of the 3 groups consisting of 15, 11, 14 subjects, respectively. We defined those who had 4 or more family members with malignant neoplasia within the third-degree relatives as members of the high risk group, while those who had no such familial history of neoplasia were defined as members of the low risk group. The lung cancer patients came from neither group. The spontaneous SCE frequency in lymphocytes of lung cancer patients was signifcantly higher than that of low risk individuals. The SCE yeilds by BP in the lymphocytes from lung cancer patients and members of the high risk group were significantly greater than members of the low risk group. The present findings suggest that members of high risk group may be more susceptible to BP than members of low risk group.

Journal

  • Haigan

    Haigan 26 (7), 737-743, 1986

    The Japan Lung Cancer Society

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