The efficacy of fexofenadine hydrochloride in chronic hemodialysis patients with pruritus-Pruritus and quality of life-

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  • 透析患者の皮膚そう痒症に対する塩酸フェキソフェナジンの有効性の検討―かゆみとＱＯＬ―
  • 透析患者の皮膚掻痒症に対する塩酸フェキソフェナジンの有効性の検討--かゆみとQOL
  • トウセキ カンジャ ノ ヒフソウヨウショウ ニ タイスル エンサン フェキソフェナジン ノ ユウコウセイ ノ ケントウ カユミ ト QOL
  • ―かゆみとQOL―

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Abstract

Pruritus is one of the most bothersome symptoms in chronic hemodialysis patients. Itchy skin may have significant negative effects on quality of life (QOL) in these patients. This study evaluated the efficacy of fexofenadine hydrochloride on pruritus in hemodialysis patients. In this prospective, open-label study, adult hemodialysis patients with pruritus (visual analogue scale (VAS) score ≥ 40) were treated with fexofenadine hydrochloride (60 mg bid) for 8 weeks. A total of 80 adult patients were enrolled. The intensity of pruritus was assessed by VAS and a specially adapted questionnaire scoring method. QOL was assessed by Skindex 29. In addition, sleep disturbance and daytime sleepiness were also assessed. After a 2-week treatment with fexofenadine hydrochloride, the intensity of pruritus including distribution of pruritus and frequency of itching was significantly improved (p<0.001) and continued to improve until the end of the study. All parameters of QOL, sleep disturbance and daytime sleepiness were also significantly improved by treatment with fexofenadine hydrochloride (p<0.001). There were no serious adverse effects during this study. In conclusion, pruritus, QOL, sleep disturbance and daytime sleepiness in hemodialysis patients were significantly improved after only 2 weeks of treatment with fexofenadine hydrochloride and continued to improve until the end of study. This study indicates that fexofenadine hydrochloride is effective for the treatment of pruritus in chronic hemodialysis patients.

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