Validity of glycemic control parameters in patients on hemodialysis: an evaluation based on continuous glucose monitoring

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  • Komi Rieko
    Department of Diabetes and Endocrinology, Shonan Kamakura General Hospital Department of Center for Clinical and Translational Science, Shonan Kamakura General Hospital
  • Ishioka Kunihiro
    Department of Kidney Disease and Transplant Center, Shonan Kamakura General Hospital Department of Center for Clinical and Translational Science, Shonan Kamakura General Hospital
  • Mochida Yasuhiro
    Department of Kidney Disease and Transplant Center, Shonan Kamakura General Hospital Department of Center for Clinical and Translational Science, Shonan Kamakura General Hospital
  • Maesato Kyoko
    Department of Kidney Disease and Transplant Center, Shonan Kamakura General Hospital Department of Center for Clinical and Translational Science, Shonan Kamakura General Hospital
  • Moriya Hidekazu
    Department of Kidney Disease and Transplant Center, Shonan Kamakura General Hospital Department of Center for Clinical and Translational Science, Shonan Kamakura General Hospital
  • Hidaka Sumi
    Department of Kidney Disease and Transplant Center, Shonan Kamakura General Hospital Department of Center for Clinical and Translational Science, Shonan Kamakura General Hospital
  • Ohtake Takayasu
    Department of Kidney Disease and Transplant Center, Shonan Kamakura General Hospital Department of Center for Clinical and Translational Science, Shonan Kamakura General Hospital
  • Kobayashi Shuzo
    Department of Kidney Disease and Transplant Center, Shonan Kamakura General Hospital Department of Center for Clinical and Translational Science, Shonan Kamakura General Hospital

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Other Title
  • 持続血糖測定 (continuous glucose monitoring: CGM) からみた血液透析患者における血糖指標の妥当性
  • ジゾク ケットウ ソクテイ(continuous glucose monitoring : CGM)カラ ミタ ケツエキ トウセキ カンジャ ニ オケル ケットウ シヒョウ ノ ダトウセイ

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Abstract

<p>【Purpose】The aim of this study was to elucidate the relationships between parameters obtained using continuous glucose monitoring (CGM) and traditional glycemic control parameters in patients on hemodialysis (HD). 【Methods】We performed 2 days of CGM in 16 HD patients and verified the usefulness of measuring glycated albumin (GA), hemoglobin A1c (HbA1c), and pre-HD glucose levels in patients on HD by comparing these parameters with CGM parameters (the mean blood glucose level, the fluctuations in the glucose level [FL], and the area under the curve of glucose above 180 mg/dL [AUCG>180]). 【Results】The mean blood glucose level exhibited significant positive correlations with the GA level and the pre-dialysis blood glucose level (p<0.01). The FL displayed significant positive correlations (r=0.585, p=0.022) with the pre-dialysis blood glucose level on the day of dialysis, the GA level on non-dialysis days (r=0.647, p<0.01), and the pre-dialysis blood glucose level (r=0.821, p=0.021). The AUCG>180 demonstrated significant positive correlations with the GA level and the pre-dialysis blood glucose level (p<0.01). There were no significant correlations between the CGM parameters and the HbA1c level. Although the pre-dialysis blood glucose level exhibited a strong correlation with the GA level (r=0.725, p<0.002), it did not display a significant correlation with the HbA1c level (r=0.414, p=0.11). 【Conclusion】The GA level and pre-HD glucose level are significantly correlated with CGM parameters in HD patients. The HbA1c level did not exhibit any association with CGM parameters. The GA level and pre-HD glucose level are useful markers of glycemic control in HD patients.</p>

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