A case of community-acquired fulminant <i>Clostridium difficile</i> colitis in a patient with end-stage renal disease

  • Morisaki Mitsuha
    Department of Internal Medicine, School of Medicine, Keio University
  • Yoshifuji Ayumi
    Department of Internal Medicine, School of Medicine, Keio University
  • Ito Tomoaki
    Department of Internal Medicine, School of Medicine, Keio University
  • Kawaguchi Takahisa
    Department of Internal Medicine, School of Medicine, Keio University
  • Shinozuka Keisuke
    Department of Internal Medicine, School of Medicine, Keio University
  • Sugita Kayoko
    Center for Infectious Disease and Infection Control, School of Medicine, Keio University
  • Nakaya Hideaki
    Department of Internal Medicine, School of Medicine, Keio University
  • Tokuyama Hirobumi
    Department of Internal Medicine, School of Medicine, Keio University
  • Hayashi Koichi
    Department of Internal Medicine, School of Medicine, Keio University
  • Hayashi Matsuhiko
    Apheresis and Dialysis Center, School of Medicine, Keio University
  • Kato Haru
    Department of BacteriologyⅡ, National Institute of Infectious Diseases
  • Wakino Shu
    Department of Internal Medicine, School of Medicine, Keio University
  • Itoh Hiroshi
    Department of Internal Medicine, School of Medicine, Keio University

Bibliographic Information

Other Title
  • 末期腎不全患者に発症し市中獲得が疑われた劇症型<i>Clostridium difficile</i>腸炎の1例
  • 症例報告 末期腎不全患者に発症し市中獲得が疑われた劇症型Clostridium difficile腸炎の1例
  • ショウレイ ホウコク マッキ ジンフゼン カンジャ ニ ハッショウ シ シ ジュウ カクトク ガ ウタガワレタ ゲキショウガタ Clostridium difficile チョウエン ノ 1レイ

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<p>Clostridium difficile colitis is considered to be a healthcare facility-associated infection caused by antimicrobial therapy; however, the number of community-acquired cases of C. difficile infection involving patients with no history of anti-microbial therapy has recently been growing. Herein, we report a case in which a patient with end-stage renal disease developed fulminant C. difficile colitis, which was suspected to be community-acquired, and exhibited melena and massive bleeding. As this was a community-acquired case, appropriate laboratory tests for C. difficile infection were not performed, resulting in a delayed diagnosis. Since end-stage renal disease put the patient in an immunocompromised state, he should have been considered to be at high risk of C. difficile infection despite the fact that he had no history of anti-microbial therapy. The present case suggested the importance of community-acquired C. difficile colitis in end-stage renal disease.</p>

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