Influence of lanthanum carbonate hydrate on magnetic resonance images

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  • Yamamuro Osamu
    Nagoya Kyouritsu Hospital East Nagoya Imaging Diagnosis Center Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University
  • Miyachi Toshiaki
    Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University

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  • 炭酸ランタン水和物がMRIに及ぼす影響
  • タンサン ランタン スイワブツ ガ MRI ニ オヨボス エイキョウ

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Abstract

<p>Lanthanum carbonate hydrate has an inhibitory effect on phosphorus absorption and is reported to be deposited on the mesenteric lymph nodes, gastric mucosa, and bone. The lanthanide paramagnetic metal gadolinium is the main contrast medium used in magnetic resonance imaging (MRI). However, the influence of gadolinium on MRI has not been fully clarified. We used 1.5 T and 3.0 T MRI scanners to image lanthanum carbonate hydrate at concentrations of 0, 0.001, 0.003, 0.01, 0.03, 0.1, 0.3, and 1.0 mol/L using spin echo and gradient echo sequences. The resultant MRI artifacts were evaluated on T1-, T2-, and T2*-weighted images, and 1/T1, 1/T2, and 1/T2* values were calculated. Lanthanum carbonate artifacts were not produced under all experimental conditions. The concentration of lanthanum carbonate hydrate exhibited proportional relationships with 1/T2 and 1/T2* (p<0.05), but had little effect on 1.5 T images. T2 and T2* were shortened by lanthanum carbonate hydrate. Higher lanthanum carbonate hydrate concentrations reduced the signal intensity of T2 images, but had little influence on T1 values.</p>

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