Characteristics of skin water content and its relationship with uremic pruritus in hemodialysis patients

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  • Nohara Tomoi
    Kidney Disease and Dialysis Center, Hidaka-kai
  • Nagano Nobuo
    Kidney Disease and Dialysis Center, Hidaka-kai Hidaka Research Center, Hidaka-kai Department of Medicine, Medical Center East, Tokyo Women's Medical University
  • Maruyama Masami
    Kidney Disease and Dialysis Center, Hidaka-kai
  • Ishida Hideki
    Kidney Disease and Dialysis Center, Hidaka-kai
  • Sekiguchi Hiroyuki
    Kidney Disease and Dialysis Center, Hidaka-kai
  • Nohara Atsushi
    Department of Diabetes and Endocrinology, Hidaka Hospital, Hidaka-kai
  • Tagahara Ayaka
    Kidney Disease and Dialysis Center, Hidaka-kai
  • Koeda Minori
    Kidney Disease and Dialysis Center, Hidaka-kai
  • Hoshi Ayako
    Kidney Disease and Dialysis Center, Hidaka-kai
  • Tamei Noriko
    Kidney Disease and Dialysis Center, Hidaka-kai
  • Takagi Chieko
    Kidney Disease and Dialysis Center, Hidaka-kai
  • Ito Kyoko
    Kidney Disease and Dialysis Center, Hidaka-kai
  • Ando Tetsuo
    Kidney Disease and Dialysis Center, Hidaka-kai
  • Tsutsui Takaaki
    Kidney Disease and Dialysis Center, Hidaka-kai
  • Ando Yoshitaka
    Kidney Disease and Dialysis Center, Hidaka-kai Department of Diabetes and Endocrinology, Hidaka Hospital, Hidaka-kai
  • Nitta Kosaku
    Department of Kidney Center, Tokyo Women's Medical University
  • Sakura Hiroshi
    Department of Medicine, Medical Center East, Tokyo Women's Medical University
  • Ogawa Tetsuya
    Kidney Disease and Dialysis Center, Hidaka-kai Department of Medicine, Medical Center East, Tokyo Women's Medical University

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Other Title
  • 透析患者における皮膚水分量の特性ならびに痒みとの関係
  • トウセキ カンジャ ニ オケル ヒフ スイブンリョウ ノ トクセイ ナラビニ ヨウミ ト ノ カンケイ

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【Objectives】To characterize uremic xerosis (dry skin) and pruritus, which are common complications in hemodialysis patients, and to evaluate the possible relationship between them. 【Methods】The prevalence and intensity of pruritus were assessed by a questionnaire survey including a visual analog scale in 450 chronic hemodialysis patients. The skin water contents at the forearm inside part and the lower back were also measured. We analyzed the relationship between pruritus and skin water content in conjunction with blood chemistry data.【Results】The overall prevalence of pruritus was 65.6% in all hemodialysis patients. The median value of arm water content was 30.9% and positively correlated with the back water content (31.2%). In contrast, the arm and back water contents did not show any relationship with gender, age, hemodialysis duration, presence of diabetes, presence of pruritus, frequency of pruritus, intensity of pruritus, presence of sleep disturbance, medication for pruritus, presence of topical cream usage nor satisfaction rating for medication. Multiple regression analysis showed that male gender, presence of diabetes, and post-dialysis serum uncorrected Ca levels were significantly and positively correlated with the presence of pruritus. Another multiple regression analysis showed that post-dialysis serum Na levels and pre-dialysis serum corrected Ca levels were selected as variables that significantly correlate with water content. 【Conclusion】Skin water content does not correlate with the presence or intensity of pruritus in chronic hemodialysis patients.

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