Changes in serum phosphate concentrations in patients on maintenance dialysis following a change in the lanthanum carbonate formulation

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  • 維持血液透析患者における炭酸ランタンの剤形変更による血清リン濃度の変化
  • イジ ケツエキ トウセキ カンジャ ニ オケル タンサン ランタン ノ ザイケイ ヘンコウ ニ ヨル ケッセイ リン ノウド ノ ヘンカ

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Abstract

 Lanthanum carbonate chewable tablets can be administered without water. However, it has been reported that phosphate (P) absorption varies according to the degree of chewing of the lanthanum carbonate tablet. To resolve this problem, a granule formulation of lanthanum carbonate has been released. We investigated P absorption when the new granule formulation of lanthanum carbonate was administered. We administered the granule formulation of lanthanum carbonate to 18 hemodialysis patients previously treated with a chewable tablet formulation of lanthanum carbonate. The mean serum P concentration significantly declined from the initial level of 5.69±0.86 mg/dL to 5.38±0.86 mg/dL at two weeks and to 5.20±1.20 mg/dL at four weeks. When the daily dose of lanthanum carbonate was higher, the decrease in the serum P concentration might be larger. No significant changes were seen in the serum calcium (Ca) or intact parathyroid hormone (iPTH) levels.

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