Associations between hemoglobin variability and hospitalization/mortality in maintenance hemodialysis patients
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- Isshiki Keiji
- Tomita Clinic
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- Hatta Tsuguru
- Division of Nephrology and Hypertension, Ohmihachiman Community Medical Center
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- Isono Motohide
- Department of Medicine, Otsu City Hospital
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- Makiishi Tetsuya
- Division of Nephrology, Japanese Red Cross Otsu Hospital (Current: Division of Nephrology, Saiseikai Shiga Hospital)
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- Nagasaku Daisuke
- Department of Medicine, Yujin-Yamazaki Hospital
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- Shingu Ryousuke
- Kita-Horie Hospital
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- Shikano Tsutomu
- Department of Medicine, Kyoto Okamoto Memorial Hospital
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- Shibuya Kazuyuki
- Department of Medicine, Kohka Public Hospital
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- Tomita Koubin
- Tomita Clinic
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- Nishio Toshiji
- Seta Clinic
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- Kanasaki Masami
- Department of Medicine, Shiga University of Medical Science
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- Araki Shin-ichi
- Department of Medicine, Shiga University of Medical Science
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- Uzu Takashi
- Department of Nephrology, Nissay Hospital
Bibliographic Information
- Other Title
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- 慢性血液透析患者におけるヘモグロビン変動と予後の関係
- 慢性血液透析患者におけるヘモグロビン変動と予後の関係 : びわこ臨床透析カンファレンス共同研究
- マンセイ ケツエキ トウセキ カンジャ ニ オケル ヘモグロビン ヘンドウ ト ヨゴ ノ カンケイ : ビワコリンショウ トウセキ カンファレンス キョウドウ ケンキュウ
- —びわこ臨床透析カンファレンス共同研究—
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Abstract
<p>【Aim】Our study aimed to examine the variability in hemoglobin (Hb) levels in Japanese hemodialysis (HD) patients to identify predictors of Hb variability and evaluate the associations between Hb variability and prognostic parameters, such as mortality at 30 months.【Patients and Methods】In this retrospective cohort study of 613 patients, Hb variability was determined using 6 months of data for the first half of 2010. Hb variability was assessed based on the residual standard deviation (Hb-RSD). We evaluated the associations between Hb variability and the risk of hospitalization or mortality in the 30-month period up to December 2012.【Results】Hb-RSD was predicted by the use of iron agents, high ferritin levels, and hospitalization in the exposure period according to multiple logistic regression analysis. The subjects were divided into high and low Hb-RSD groups according to the median Hb-RSD, and the high Hb-RSD group was at higher risk of hospitalization and had a lower survival rate than the low Hb-RSD group (Kaplan-Meier analysis and the log-rank test). Hb-RSD was found to be associated with the risk of all-cause mortality during 30 months' follow-up (Cox proportional hazard model analysis, hazard ratio: 2.54, 95% confidence interval; 1.06-6.06, p=0.036).【Conclusion】Hb-RSD independently predicts mortality over a 30-month period. Hb-RSD might be a predictor of the risk of mortality in HD patients.</p>
Journal
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- Nihon Toseki Igakkai Zasshi
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Nihon Toseki Igakkai Zasshi 50 (7), 465-472, 2017
The Japanese Society for Dialysis Therapy
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Keywords
Details 詳細情報について
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- CRID
- 1390282679657474176
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- NII Article ID
- 130005868576
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- NII Book ID
- AN10432053
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- ISSN
- 1883082X
- 13403451
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- NDL BIB ID
- 028448592
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed