Bronchial Arterial RI-Angiography. Evaluation of Regional Blood Flow in Pulmonary Cancer Using 99mTcO4- and 99mTc-MMA.

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Other Title
  • 経気管支動脈性RI‐Angiography 2核種による肺癌の局所血流の評価
  • 経気管支動脈性RI-Angiography : 2核種による肺癌の局所血流の評価
  • ケイキカンシ ドウミャクセイ RI-Angiography : 2カクシュ ニヨル ハイガン ノ キョクショ ケツリュウ ノ ヒョウカ
  • Evaluation of Regional Blood Flow in Pulmonary Cancer Using <SUP>99m</SUP>TcO<SUB>4</SUB>- and <SUP>99m</SUP>Tc-MMA
  • 2核種による肺癌の局所血流の評価

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Abstract

Thirteen bronchial arterial perfusion studies were performed in a total of 13 patients with lung tumors (11 cases of lung cancer, one metastatic tumor and one abscess), utilizing 99mTcO4- or 99mTc-Jabeled macroaggregated albumin (99mTc-MAA). Regions of interest (ROI) of the same size were set over areas of tumor, the mediastinum and healthy lung areas, and each ROI count was calculated by a nuclear medicine computer during an acquisition time period of 20 min with each tracer for 7 min to evaluate tumor part perfusion. The count ratios of tumor to healthy parts ranged from 1.7 to 6.5 (mean±s.d.; 3.8±1.9) in the 99mTcO4- group (10 patients) and from 130 to 230 (mean±s.d.; 163±30) in the 99mTc-MAA group (3 patients), respectively. Tumor reduction rates 2 weeks after CDDP bronchial artery infusion therapy correlated positively to the count ratio in the 99mTcO4- lung cancer group, although significant correlation was not obtained. This study suggests that bronchial arterial infusion of anticancer agents may result in higher concentrations of anticancer agents in the tumors than with systemic chemotherapy and chemoembolic materials may exert more potent anticancer effects on tumors than nonparticulated anticancer agents.

Journal

  • Haigan

    Haigan 32 (4), 489-495, 1992

    The Japan Lung Cancer Society

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