Immunoabsorption plasma pheresis (IAPP) therapy for neuromyelitis optica (NMO) spectrum disorders in two cases

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  • Sugisaki Kentaro
    Division of Nephrology, Tokyo Medical University Hachioji Medical Center
  • Nakabayashi Iwao
    Division of Nephrology, Tokyo Medical University Hachioji Medical Center
  • Kojima Tadasu
    Division of Nephrology, Tokyo Medical University Hachioji Medical Center
  • Tomiyasu Tomohiro
    Division of Nephrology, Tokyo Medical University Hachioji Medical Center
  • Akashi Masakazu
    Division of Nephrology, Tokyo Medical University Hachioji Medical Center
  • Ioya Noriko
    Division of Nephrology, Tokyo Medical University Hachioji Medical Center
  • Yoshida Masaharu
    Division of Nephrology, Tokyo Medical University Hachioji Medical Center

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Other Title
  • 免疫吸着療法（ＩＡＰＰ）により軽快しえた視神経脊髄炎（ＮＭＯ）関連疾患の２例
  • 症例報告 免疫吸着療法(IAPP)により軽快しえた視神経脊髄炎(NMO)関連疾患の2例
  • ショウレイ ホウコク メンエキ キュウチャク リョウホウ IAPP ニ ヨリ ケイカイ シエタ シシンケイ セキズイエン NMO カンレン シッカン ノ 2レイ

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Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system that causes severe optic neuritis and myelitis attacks. The association of NMO with serum autoantibody marker NMO-IgG was reported in 2004. The effectiveness of immunoabsorption plasma pheresis (IAPP) therapy for treating acute exacerbations of NMO has not been well evaluated; thus, accumulation of therapeutic experience for this disease is important. We report 2 patients with acute exacerbations of NMO spectrum disorders, although neither patient has demonstrated optic neuritis to date. Both patients were unresponsive to intravenous methylprednisolone therapy, but showed significant improvement after IAPP therapy, which allowed us to reduce the immunosuppressive medications. In conclusion, IAPP therapy may be one of therapeutic options for patients demonstrating a fulminant attack of NMO.

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