Non-collagenous proteins in bone: Osteocalcin and osteonectin

DOI 2 Citations Open Access
  • Sasaki Satoshi
    Department of Biochemistry, School of Dentistry, Tokyo Medical and Dental University

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  • 骨の非コラーゲン性たんぱく質　　オステオカルシンとオステオネクチン

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Importance of non-collagenous proteins, especially osteocalcin and osteonectin in calcification was reviewed.<BR>Osteocalcin is a γ-carboxyglutamic acid-containing protein in bone and synthesized by osteoblasts vitamin K-dependently. Osteocalcin has characteristic properties of Ca-binding and also adsorption to hydroxyapatite crystal. These properties and the appearance in developing bone strongly suggest some regulatory roles in bone calcification process.<BR>Osteonectin is another bone-specific protein which has a property to bind selectively to both hydroxyapatite and type I collagen. This protein is found to be present in newly calcified bone tissue and in osteoblasts but not in soft tissues by immunofluorescent detection. These studies suggest that osteonectin may play a role in initiating calcification.

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