Study on Hereditary pattern of the Mandible Shape in Multiple Models of Inbred Mouse Strains

DOI 2 Citations 14 References
  • Okamoto Kazuhisa
    Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo
  • Dohmoto Atsushi
    Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo
  • Takei Kenji
    Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo
  • Ohta Takuya
    Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo
  • Komiya Johji
    Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo
  • Matsubara Kiyoshi
    Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo
  • Asada Yoshinobu
    Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo
  • Maeda Takahide
    Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo

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  • 近交系マウス複数モデルを用いた下顎骨形態の遺伝に関する研究

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We have previously reported that the horizontal dimensions were predominantly inherited in the murine mandible, using one model of MRL/n strain mice with large mandibles and C 57 BL/6 By mice with small mandibles in the parents, and F 1 and F 1' hybrids used as reciprocal cross.<BR>In this study, we added two models of different inbred mice in the same manner in the previous experiment, these being were RF/J and C 57 L/6 J strains with large mandibles, and SMIJ and A/HeJ strains with small mandibles in the parents.7 (RF/J female × SM/J male) F 1 and 11 (SM/J female × RF/J male) F 1', and 22 (C 57 L/6 J female × A/HeJ male) F 1 hybrids were used. The inter-landmark distances of the right mandible were measured using an electronic digitizer. Based on the mandibular plane as the X axis, some inter-landmark distances were divided into X-components for the horizontal and Y-components for the vertical dimensions. In all of the F 1 types of these three models, the X omponent of the distance from the mental region to the mandibular angle and the distance from the-c mental region to the condylar process showed the same or higher trends as the parents with large mandibles. Since these two inter-landmark distances indicating anterior growth of the mandible significantly showed dominance in the large characteristics of the murine mandible, we suggest that these lengths of the two distances become the phenotype to elucidate the gene affecting their growth.

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