Immunopathological study of salivary glands

DOI

Bibliographic Information

Other Title
  • だ液せんの免疫病理学的研究　ＩＶ　　ＤＮＡ長期接種によるラットだ液せんおよび涙せんの反応性
  • 第4報: DNA長期接種によるラット唾液腺および涙腺の反応性

Abstract

Immunopathological study of the salivary and lacrymal glands of SD-rats which inoculated with DNA antigen once a week over a period of ten months was attempted. Histopathological observation revealed manifestation of the lesion with infiltration or proliferation of numerous lymphocytes in the group treated after six months of final inoculation, but no change was seen in the group collected the spesimens after one week of the inoculation. The lymphocytes mainly consisted of nonhelper T cell and other immune competent cell such as B-cell and helper T cell barely observed in the lesion.<BR>It was considered that ADCC and cytotoxic factor by the lymphocyte population were related to the glandular cell injuries. From the nature of lymphocyte subset, it was indicated that non-helper T cell subset which possesed Fc receptor to IgG held principal position to the salivary and lacrymal tissue injuries by ADCC and cytotoxic factor.

Journal

Keywords

Details 詳細情報について

  • CRID
    1390282679659177984
  • NII Article ID
    130004001139
  • DOI
    10.2330/joralbiosci1965.25.130
  • ISSN
    03850137
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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