肺小細胞癌の病理組織学的検討

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タイトル別名
  • HISTOPATHOLOGICAL ANALYSIS OF SMALL CELL CARCINOMA OF THE LUNG
  • With a Special Reference to Histological Features and Intrapulmonary Spreading
  • 殊に, 組織像と肺内局所進展様相について

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説明

Small cell carcinomas seen at National Cancer Center Hospital during the period from 1962 through 1975 were reviewed. Among 35 surgically resected tumors, there were 6 tumors of oat cell type, 24 of intermediate cell type and 5 others. And in 110 autopsy cases, 53 were of oat, cell type, 47 of intermediate cell type and 8 unclassified. Some of intermediate cell type revealed areas with other histologic features, such as squamous and glandular. The transition between oat cell type and intermediate cell type was noted frequently even within a single tumor.<BR>Small cell carcinoma grew often along the bronchial wall, particularly beneath the epithelium and along the submucosal lymphatics, resulting in diffuse thickening of the lining of the major bronchi. At the periphery of the lung, they grew within alveolar spaces without destroying the alveolar architectires. Gross features of small cell carcinoma of intermediate cell type with squamous cell or glandular differentiation resembled those of poorly differentiated squamous cell or adenocarcinoma, respectively. Prognosis of patients with these tumors was better than that of patients with oat cell type. Based on histological characteristics, gross features and prognosis, subclassifi cation of small cell carcinoma is proposed.

収録刊行物

  • 肺癌

    肺癌 17 (1), 31-45, 1977

    特定非営利活動法人 日本肺癌学会

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