The Current Situation and Problems of Re-biopsy in Non-small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations
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- Tsuya Asuka
- Department of Medical Oncology, Osaka City General Hospital
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- Shibata Yumi
- Department of Medical Oncology, Osaka City General Hospital
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- Katsushima Utae
- Department of Medical Oncology, Osaka City General Hospital
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- Akiyoshi Kohei
- Department of Medical Oncology, Osaka City General Hospital
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- Tokunaga Shinya
- Department of Medical Oncology, Osaka City General Hospital
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- Daga Haruko
- Department of Medical Oncology, Osaka City General Hospital
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- Sumitani Mitsuhiro
- Department of Respiratory Medicine, Osaka City General Hospital
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- Shoji Seiichi
- Department of Respiratory Medicine, Osaka City General Hospital
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- Takeda Koji
- Department of Medical Oncology, Osaka City General Hospital
Bibliographic Information
- Other Title
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- EGFR遺伝子変異陽性非小細胞肺癌のre-biopsyの現状と課題
Abstract
<p>Objective and Method. We examined the changes in the EGFR mutation status, including the frequency of acquired T790M mutations, in 25 non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations who underwent a re-biopsy (include pleural effusion) from January 2013 to March 2015. Results. The male:female ratio was 7/18, at the time of the initial chemotherapy the median age was 67 years (range, 33-77), the types of EGFR mutation included exon19 del (n=12), L858R (n=11), L858R+T790M (n=1), and T751-I759 del ins N (n=1). Eighteen patients were treated with gefitinib as first-line treatment, and 12 patients underwent a re-biopsy just before the administration of a second-line treatment. The biopsy sites at the initial examination were the primary lung tumor (n=21), pleural dissemination (n=1), the bone (n=2), and pleural effusion (n=1). The biopsy site at re-biopsy was the primary tumor (n=9), pleural effusion (n=15), and the lymph nodes (n=1). At re-biopsy, 10 patients (40%) had acquired the T790M mutation. In four cases that received a biopsy using a bronchoscope, the results between the specimen and a mutation analysis were discordant. Conclusion. The presence of a resistance gene affects the choice of subsequent treatment. However, the ability to perform a genetic analysis using biopsied tissue samples is limited. We should therefore consider the use of cytology specimens, including fluid samples.</p>
Journal
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- Haigan
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Haigan 56 (5), 331-336, 2016
The Japan Lung Cancer Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679660421760
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- NII Article ID
- 130005279087
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- ISSN
- 13489992
- 03869628
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed