A Basis of Molecular Pathology for Clinicians

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  • Yatabe Yasushi
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center

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  • 臨床医のための分子病理診断の基礎

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Abstract

It has been a part of daily practice to select patients for targeted therapies according to the results of genetic testing analyses. A basis of tumor molecular pathology is required to understand the advantages and disadvantages of the methods for the proper evaluation of the results. There are two types of cancer-associated genes: oncogenes and tumor suppressor genes. Currently, most molecular targeted therapies are developed for oncogenes, which can be categorized into four major genetic alterations. In this review, the four major genetic alterations, including gene mutation, gene amplification, gene rearrangement and protein overexpression, are reviewed and the detection methods and tissues types to be examined are discussed.

Journal

  • Haigan

    Haigan 55 (6), 986-990, 2015

    The Japan Lung Cancer Society

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