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- 福本 敏
- 九州大学大学院歯学研究院口腔保健推進学講座 小児口腔医学分野(小児歯科)
書誌事項
- タイトル別名
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- Molecular Mechanisum of Tooth Morphogenesis Regulated by Extracellular Matrix
この論文をさがす
説明
Tooth regeneration is one of the final goal of dental science. However, it is difficult to form proper tooth containing enamel, dentin and cementum. In this study, we focused on the function of extrecellular matrix, especially enamel matrix protein, which is essential for the enamel formation.<BR>Ameloblastin is one of the enamel matrix protein secreted by ameloblasts. This involved in the determination of cell polarity, regulation of proliferation and secretion of amelogenin. In ameloblastin null-mutants, severe enamel hypoplasia was observed. This phenotype was similar to human amelogenesis imperfecta. Furteher, the mutant mice developed an odontogenic tumor of dental epithelium origin. Thus, ameloblastin is one of the affected gene of amelogenesis imperfecta, and may inhibit tumor growth of odontogenic tumor as a therapeutic agents.
収録刊行物
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- The Japanese Journal of Pediatric Dentistry
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The Japanese Journal of Pediatric Dentistry 43 (3), 380-384, 2005
The Japanese Society of Pediatric Dentistry
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詳細情報 詳細情報について
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- CRID
- 1390282679662093312
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- NII論文ID
- 10016566540
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- NII書誌ID
- AN00116228
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- ISSN
- 05831199
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
