肺のｌａｒｇｅ　ｃｅｌｌ　ｎｅｕｒｏｅｎｄｏｃｒｉｎｅ　ｃａｒｃｉｎｏｍａ　２例の細胞像

DOI 被引用文献1件 参考文献7件

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  • Two cases of large cell neuroendocrine carcinoma of the lung.

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Background: Carcinoid and small-cell carcinoma are known as neuroendocrine tumors in primary pulmonary carcinoma. The current World Health Organization (WHO) classification includes a new independent category of large-cell neuroendocrine carcinoma (LCNEC), that is morphologically and biologically an intermediate degree of malignancy between carcinoid and small-cell carcinoma. We detail cytological findings in 2 cases of LCNEC we observed.<BR>Cases: Subjects were 2 men-one 68 years old and the other 71 years-old. Cytological findings showed large and small cell groups including rosette-like structures and filamentous groups. Many tumor cells were oval or spindle-shaped. Tumor cells showed a high N/C ratio, and had slight lightgreen staining or granular cytoplasms. Nuclei were oval, and each nucleus was located in the center of the cell. A thin nuclear membrane and fine chromatin were observed. Nuclear lines were rare or absent.<BR>Conclusion: Cytological findings for our 2 subjects were similar to those in conventional reports in the size of tumor cell, nuclei, and cell groups. Cytological findings of oval nuclei, a thin nuclear membrane, fine chromatin, and the rarity or absence of nuclears lines in the background are considered diagnostically important.

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