Arteriosclerosis in Children and Young Adults

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  • NAKAZAWA Kaori
    Department of Pathology, Nihon University School of Medicine
  • SAKURAI Isamu
    Department of Pathology, Nihon University School of Medicine
  • MORI Yoshiomi
    Department of Pathology, Dokkyo University School of Medicine, Koshigaya Hospital
  • SEGI Kazuko
    Department of Pathology, Nihon University School of Medicine
  • KOMATSU Akio
    Department of Pathology, Saitama Children's Medical Center
  • OSADA Hiromi
    Department of Pathology, Nihon University School of Medicine
  • NAKAMURA Mani
    Department of Pathology, Nihon University School of Medicine

Bibliographic Information

Other Title
  • 小児・若年者における動脈硬化
  • ―冠動脈と大動脈の比較―
  • -Comparative Study on Coronary Arteries and Aortae-

Abstract

It has been widely recognized that arteriosclerosis is a silent disease for a long period of time during its progressive stage. Therefore, it seems reasonable to think very important for early stage of it to be investigated in children and young adults.<br>This study was aimed to make the differences clear between coronary arteries and aortae for the purpose of elucidation of local factor (s) of progression of sclerosis.<br>Arteriosclerotic index was caliculated by the method of point counting and Gore's score given to severity of arteriosclerosis, was significantly higher in the aortae (398 cases) than in the coronary arteries (314 cases). In contrast, microscopically proven intimal thickening had significant tendencies that coronary arteries (126 cases) was stronger than aortae (233 cases). Coronary arteries has characteristics of fibrocellular proliferation and weaker lipid deposition in thickened intima, while aortae was characterized by significant lipid deposition in thinner intima. Vasa vasorum became more prominent microscopically in coronary arteries, as intimal thickening progressed, but they did not so in aortae. Circulatory disturbances within the wall might be one of local factors as to coronary arteries.

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