コレスチポールのラット胆汁酸代謝に対する影響

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  • Effect of Colestipol on Bile Acid Metabolism in the Rat

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Bile acid metabolism was examined in Sprague-Dawley male rats on 2 per cent colestipol diet, 5 per cent cholesterol diet or both. In the colestipol group, there was an about three folds increase in fecal bile acids and a slight increase in fecal neutral sterols. The composition of bile acid was altered to precominantly cholic acid group bile acid. In the cholesterol group, there was a increase in fecal bile acids and composition of bile acid was altered predominantly chenodeoxycholic acid group bile acid.<br>The composition of bile acid in the large intestine was similar to that of feces, which suggested that bile acids were scarcely absorbed in the large intestine. Bile acids of small intestine slightly decreased in the colestipol group and significantly decreased in the cholesterol -colestipol group. Secretion of bile acids descreased in the colestipol group. There was an eminent increase in the primary bile acid of the bile and small intestine in the colestipol and cholesterol-colestipol group.<br>Bile acid pool size decreased in the colestipol group and the cholesterol-colestipol group and did not change in the cholesterol group. The activities of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol-7-hydroxylase increased in the colestipol group.<br>These findings suggested that colestipol administration altered the bile acid metabolism including bile acid pool size, composition and distribution.

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