Change of Cholesterol Esterase Activity in Rat Parametrial Adipose Tissue Due to Ovariectomy, and its Mechanism

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  • 卵巣摘出による脂肪組織コレステロールエステラーゼ活性の低下とそれに伴うA-蛋白キナーゼの低下

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Abstract

CEase activity in rat adipose tissue was determined using a micellar substrate. This substrate was found more suitable than a liposomal substrate in respect of Km and Vmax. The activity was enhanced by c-AMP, ATP, Mg2+, and A-Kinase from bovine hearts. A nine-week duration of OV-X significantly decreased serum estradiol level (30%) and CEase activity (41%) in the parametrial adipose tissue. In contrast, orchiectomy failed to exert such an effect on the epididymal adipose tissue. The content of c-AMP in the parametrial adipose tissue was unaltered due to OV-X, but the A-Kinase activity was attenuated in parallel to the change in the CEase activity. It is suggested that the change in CEase activity due to OV-X is reflected by the A-Kinase activity.

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