The evaluation of cytologic findings of breast disease using multivariate statistical analysis.

DOI 2 Citations
  • FUKASAWA Masakatsu
    Pathological Laboratory, University Hospital, University of Tsukuba
  • YOSHIDA Akira
    Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
  • SHIGEMITSU Sadahiko
    Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba
  • TANAKA Hideyuki
    Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
  • USHIO Hiroki
    Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
  • UENO Ei
    Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
  • AIYOSHI Yuji
    Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
  • KANMA Hiroshi
    Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba
  • OGATA Takesaburo
    Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba

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Other Title
  • 多変量解析を用いた乳腺細胞所見の評価

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Abstract

We quantied 17 cytologic findings in aspiration cytology specimens in order to determine the diagnostic value of each finding.<BR>In 101 cases of breast disease (50 carcinomas and 51 benign diseases), the degree of the respective cytologic findings was quantified by the appropriate scales. Then, the category score and the coefficient value of each cytologic finding were calculated by using multivariate statistical analysis.<BR>The following cytologic findings showed high coefficient values; distribution of chromatin, nuclear shape, chromatin pattern, naked bipolar nuclei, intercellular connection, and paired cells. These were considered to be important in the diagnosis of breast diseases. The distribution of “total category score” was quite different in malignant and benign cases. In addition, the usefulness of this category score was proved by an external check, which was performed on 20 additional cases.

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