Cytological characteristics of mucinous carcinoma of the breast in the elderly with bibliographical considerations

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  • SHIRAHATA Hiroto
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital
  • HONMA Naoko
    Department of Pathology, School of Medicine, Toho University
  • KOTANI Takashi
    Department of Laboratory Medicine, Tokyo Dental College Ichikawa General Hospital
  • IMAIZUMI Masayuki
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital
  • HAMASHIMA Yuri
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital
  • ESAKA Shikine
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital
  • KINOSHITA Mayumi
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital
  • SUZUKI Akemi
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital
  • SAKURAI Urara
    Department of Pathology, Musashino Red Cross Hospital
  • ARAI Tomio
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital

Bibliographic Information

Other Title
  • 高齢者における乳腺粘液癌の細胞学的検討と文献的考察
  • Cytological Characteristics of Mucinous Carcinoma of the Breast in the Elderly with Bibliographical Considerations (in Japanese with English Abstract)

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Abstract

<p>Objective : The aim of this study was to clarify the cytological characteristics of mucinous carcinoma of the breast in the elderly.</p><p>Study Design : We studied the cytological features, as well as the histopathological and immunohistochemical features, of mucinous carcinoma of the breast in 13 elderly patients with a review of the related literature.</p><p>Results : The 13 mucinous carcinomas were classified into Type A (hypocellular variant ; n=3) and Type B (hypercellular variant ; n=10) tumors. All the Type B tumors, but none of the Type A tumors, had a non-infiltrating component. The Type B tumors showed a high positivity rate for the estrogen receptor (ER), progesterone receptor (PgR), gross cystic disease fluid protein-15 and neuroendocrine markers, whereas the Type A showed a positive reaction only for ER. Cytologically, both Type A and Type B tumors showed large amount of mucus and a large vascular component. Type B tumor cells showed a tendency towards loss of ability for cellular adhesion. Three Type B tumors showed the characteristic features of neuroendocrine tumors, while the rest of the Type B and Type A tumors showed stronger nuclear atypia.</p><p>Conclusion : Our results suggest that mucinous carcinomas of the breast in the elderly show cytological diversity, probably due to the higher proportion of Type B carcinomas with neuroendocrine differentiation and a high frequency of Type A carcinomas also showing Type B-like characteristics.</p>

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