PAR-1/MARK: a Kinase Essential for Maintaining the Dynamic State of Microtubules
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- Hayashi Kenji
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
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- Suzuki Atsushi
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
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- Ohno Shigeo
- Department of Molecular Biology, Yokohama City University Graduate School of Medical Science
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Abstract
The serine/threonine kinase, PAR-1, is an essential component of the evolutionary-conserved polarity-regulating system, PAR-aPKC system, which plays indispensable roles in establishing asymmetric protein distributions and cell polarity in various biological contexts (Suzuki, A. and Ohno, S. (2006). J. Cell Sci., 119: 979–987; Matenia, D. and Mandelkow, E.M. (2009). Trends Biochem. Sci., 34: 332–342). PAR-1 is also known as MARK, which phosphorylates classical microtubule-associated proteins (MAPs) and detaches MAPs from microtubules (Matenia, D. and Mandelkow, E.M. (2009). Trends Biochem. Sci., 34: 332–342). This MARK activity of PAR-1 suggests its role in microtubule (MT) dynamics, but surprisingly, only few studies have been carried out to address this issue. Here, we summarize our recent study on live imaging analysis of MT dynamics in PAR-1b-depleted cells, which clearly demonstrated the positive role of PAR-1b in maintaining MT dynamics (Hayashi, K., Suzuki, A., Hirai, S., Kurihara, Y., Hoogenraad, C.C., and Ohno, S. (2011). J. Neurosci., 31: 12094–12103). Importantly, our results further revealed the novel physiological function of PAR-1b in maintaining dendritic spine morphology in mature neurons.<br>
Journal
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- Cell Structure and Function
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Cell Structure and Function 37 (1), 21-25, 2012
Japan Society for Cell Biology
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Details 詳細情報について
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- CRID
- 1390282679671047040
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- NII Article ID
- 130004053887
- 40019581864
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- NII Book ID
- AA0060007X
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- ISSN
- 13473700
- 03867196
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- NDL BIB ID
- 024272050
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed