Analysis of orangeophilic cells in effusion cytology

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  • 体腔液検体中に認められるオレンジＧ好性細胞の検討

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Objective: Cells with orange-colored cytoplasm (orangeophilic cells) are sometimes found in Papanicolaou-stained smears of serous effusions. We studied the frequency of their occurrence in effusions of various origins.<br>Study Design: We retrospectively studied cytocentrifuged cell smears stained by Papanicolaou, i. e., 24 malignant mesotheliomas (MM), 53 reactive mesothelia (RM), 25 pulmonary adenocarcinomas (PAC), and 13 ovarian serous papillary adenocarcinomas (OSPAC). The numbers of orangeophilic cells were counted in each specimen.<br>Results: Orangeophilic cells were observed in 18 (75.0%) MM, 2 (3.8%) RM, 2 (8.0%) PAC, and 3 (23.1%) OSPAC. Twelve (50.0%) MM, 1 (1.9%) RM, 1 (4.0%) PAC, and 1 (7.7%) OSPAC contained 5 or more orangeophilic cells in each specimen. The frequency in MM was statistically higher than in RM, PAC, or OSPAC (p<0.001).<br>Conclusions: Orangeophilic cells are very often found in effusions of MM, and are useful findings to differ MM from others. When we find orangeophilic cells in a specimen, we must carefully examine for MM. The presence of orangeophilic cells, especially 5 or more, is thus useful for diagnosing MM in serous effusions.

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