Transcriptional Activation of Mouse Major Satellite Regions during Neuronal Differentiation
-
- Kishi Yusuke
- Institute of Molecular and Cellular Biosciences, The University of Tokyo
-
- Kondo Shigeki
- Institute of Molecular and Cellular Biosciences, The University of Tokyo
-
- Gotoh Yukiko
- Institute of Molecular and Cellular Biosciences, The University of Tokyo
Bibliographic Information
- Other Title
-
- Adenosine A2A Receptor Facilitates Calcium-Dependent Protein Secretion through the Activation of Protein Kinase A and Phosphatidylinositol-3 Kinase in PC12 Cells
Search this article
Description
Recent studies have revealed various biological functions for repetitive sequences, which make up about half of the human genome. One such sequence, major satellites, which are tandem repetitive sequences adjacent to the centromere, have been shown to be a kinetochore component that plays a role in the formation and function of the pericentric heterochromatin necessary for mitosis. However, it is unknown whether these regions also play a role in post-mitotic cells. Here, we show that, during neuronal differentiation, the heterochromatin domains that include major satellite regions become both enriched with the active histone modification lysine-4 trimethylation of histone H3, and more sensitive to nuclease, both of which suggest increased activation of this area. Further supporting this notion, we also found that transcription from major satellite regions is significantly increased during neuronal differentiation both in vitro and in vivo. These results together suggest that the structural and transcriptional state of major satellite regions changes dramatically during neuronal differentiation, implying that this region might play a role in differentiating neurons.
Journal
-
- Cell Structure and Function
-
Cell Structure and Function 37 (2), 101-110, 2012
Japan Society for Cell Biology
- Tweet
Details 詳細情報について
-
- CRID
- 1390282679672901120
-
- NII Article ID
- 130004137582
- 130004053851
- 10014273720
-
- NII Book ID
- AA0060007X
-
- COI
- 1:STN:280:DC%2BC38bmvVSqtw%3D%3D
-
- ISSN
- 13473700
- 03867196
-
- Web Site
- http://id.ndl.go.jp/bib/7212323
- https://ndlsearch.ndl.go.jp/books/R000000004-I7212323
- http://id.ndl.go.jp/bib/024272276
- https://ndlsearch.ndl.go.jp/books/R000000004-I024272276
- http://www.jstage.jst.go.jp/article/csf/29/4/29_4_101/_pdf
- https://www.jstage.jst.go.jp/article/csf/37/2/37_12009/_pdf
- https://search.jamas.or.jp/link/ui/2014093262
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
-
- Abstract License Flag
- Disallowed