A case of mucoepidermoid carcinoma which could be diagnosed by liquid based bronchial brushing cytology
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- FUKUMITSU Chihiro
- Department of Diagnostic Pathology, Kurume University Hospital
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- KAWAHARA Akihiko
- Department of Diagnostic Pathology, Kurume University Hospital
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- YAMAGUCHI Tomohiko
- Department of Diagnostic Pathology, Kurume University Hospital
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- ABE Hideyuki
- Department of Diagnostic Pathology, Kurume University Hospital
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- TAIRA Tomoki
- Department of Diagnostic Pathology, Kurume University Hospital
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- TAKASE Yorihiko
- Department of Diagnostic Pathology, Kurume University Hospital
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- AKIBA Jun
- Department of Pathology, Kurume University School of Medicine
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- KAGE Masayoshi
- Department of Diagnostic Pathology, Kurume University Hospital
Bibliographic Information
- Other Title
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- 液状細胞診にて診断した気管支腺原発の粘表皮癌の 1 例
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Abstract
Background : Mucoepidermoid carcinoma of the bronchus is a rare malignant tumor. We report a case of mucoepidermoid carcinoma which could be diagnosed by liquid based cytology (LBC) of bronchial brushings.<br>Case : A 20-year-old man with an abnormal opacity in the right lung hilum was diagnosed as having bronchiectasis. A mass lesion was present in the right bronchial lumen, and LBC of bronchial brushings was performed. The tumor cluster was arranged in sheets or three-dimensional gland-like structures. The tumor cells showed an elevated N/C ratio and slight irregularity of the nuclear shapes, and included mucous cells and squamous cells. On immunocytochemistry, the tumor cells showing squamous differentiation were p63-positive and the mucous cells were human gastric mucin-positive. The tumor was diagnosed as a mucoepidermoid carcinoma. Histologically, the tumor consisted of a solid tumor with large and small cystic spaces in fibrous connective tissue a fibrous stroma. The tumor cells consisted of mucous and squamous and intermediate cells. The Ki-67 labeling index of the tumor cells was under 1% on immunohistochemistry. We finally diagnosed the tumor as low-grade mucoepidermoid carcinoma.<br>Conclusions : LBC revealed three-dimensional clusters reflecting tissue structures, as compared to conventional smears. Therefore, these findings should be borne in mind when using LBC for diagnosis.
Journal
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- The Journal of the Japanese Society of Clinical Cytology
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The Journal of the Japanese Society of Clinical Cytology 52 (5), 473-477, 2013
The Japanese Society of Clinical Cytology
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Details 詳細情報について
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- CRID
- 1390282679673224320
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- NII Article ID
- 10031191694
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- NII Book ID
- AN00198721
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- ISSN
- 18827233
- 03871193
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed