26尿中アミノアセトフェノン関連物質について

  • 綛󠄄田 博紀
    和歌山県立医科大学応用医学研究所病態生化学
  • 野口 知雄
    和歌山県立医科大学応用医学研究所病態生化学
  • 城戸 亮
    和歌山県立医科大学応用医学研究所病態生化学

書誌事項

タイトル別名
  • Urinary Aminoacetophenone Derivatives and Their Biosynthesis

この論文をさがす

説明

Studies were carried out on the urinary excretion and biosynthetic pathways of aminoacetophenone derivatives.<BR>1. Administration of tryptophan to hens or rats resulted in occurrence of aminoacetophenone (AAP), 2-amino-3-hydroxyacetophenone (3 HAAP) and 2-amino- 5-hydroxyacetophenone (5 HAAP).<BR>2. Kynurenine was enzymically converted to kynurenamine by 0.01 M phosphate buffer (pH 8. 0) extract of rat liver and then non enzymically to AAP.<BR>3. 5HAAP was formed from 5-hydroxykynurenine via 5-hydroxykynurenamine by 0.01 M phosphate buffer (pH 8. 0) extract of rat small intestine through the similar route to that of formation of AAP from kynurenine.<BR>4. Rat liver rnicrosomes catalyzed hydroxylation of AAP to yield 3HAAP in the presence of NADPH.

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ