EXPERIMENTAL STUDIES ON METHYL-ETHYL-KET-OXIME TOXICITY : REPORT 1. ON ACUTE POISONING BY MEK-OXIME

KURITA Hideo, MATSUSHITA Toshio

doi:10.1539/joh1959.6.2_51

On the surface of paints, varnish, enamel or lacguer kept in vessels for a long time, a hard gummy membrane is formed due to oxidation by air. Hitherto, many kinds of chemical substances have been used to protect such membrane formation, and usefulness of MEK-Oxime for this purpose was found out in the U.S.A. about 1940. As also in Japan it has been commercialized since 1962, it is supposed that the number of workers exposed to it will hereafter increase in Japan. These studies were taken up for the purpose of clarifying MEK-Oxime toxicity. Experimental Methods and Results 1. LD₅₀ to Rats. The animals used were male albino rats, average body weight 125 g, and divided into 7 groups each consisting of 6 rats. MEK-Oxime was injected subcutaneously at dosages shown in the Table. Results were: i) By Behrens-Karber Method. LD₅₀=2, 701.5 mg/kg B.W. [table] (2.93 cc/kg B.W.) ii) By Van der Warden Method. LD₅₀=2, 761.6-2, 813.2 mg/kg B.W. (2.99-3.05 cc/kg B.W.) 2. Application on the Skin of Rats. 3 rats, A group, were applied 0.4 cc MEK-Oxime with vaseline on their necks and 2 rats, as the control, B group were applied only vaseline once a day for 5 weeks. In 2 rats among A group, the following dermatological changes were observed: wettish erythem on the 4th experimental day, papule or local erosion on the 6th-7th day, thin and small squama like crusta on about the 10th days. These were almost cured except slight hypertrophy of the corneous layer after about fifteen days. In another rat of A group and two rats of B group, any abnormal changes of the skin were scarcely observed. 3. Exposure to Saturated Vapour. Two rats were put in a chamber of about 0.08 m³ filled with saturated MEK-Oxime vapour and their behavior were abserbed. 4. Instilling into the Eye. Soon after dropping MEK-Oxime into one of the eyes of each 3 rats, heavy hyperemia appeared on the eye-lid and the eye bulb conjunctive. Then, the animals wiped repeatedly their eyes with their legs and shaked their heads. These behavior are regarded as owing to eye-ache. After a few minutes hyperemia was recognized on the other eye, too. These symptoms reduced gradually, and disappeared after 9 hours. 5. Symptoms of acute poisoning by MEK-Oxime seems to resemble to those by Methyl-Ethyl-Ketone (Butanon) rather than those by other Oximes and metabolites of MEK-Oxime.

EXPERIMENTAL STUDIES ON METHYL-ETHYL-KET-OXIME TOXICITY : REPORT 1. ON ACUTE POISONING BY MEK-OXIME

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