AN EXPERIMENTAL STUDY ON THE POISONING BY DNX IN COMPARISON WITH TNT

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  • 動物実験によるDNX (Dinitroxylene)とTNT (Trinitrotoluene)の毒性について
  • ドウブツ ジッケン ニ ヨル DNX Dinitroxylene ト TNT Trinitrotoluene ノ ドクセイ ニ ツイテ

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Abstract

Recently, DNX (dinitroxylene), a derivative of aromatic nitro compound, has been used as a substitute for TNT in Japanese explosive industries. But there exsist little reports on DNX-poisoning except the Perkins' (1918). An experimental study on the poisoning by DNX in comparison with TNT was performed. Animals used in this study were rabbits divided into 7 groups, each group consisting of 3 rabbits. Every day, each group was treated as follows. A group; injected subcutaneously with DNX 50mg/kg. B group; injected subcutaneously with TNT 50mg/kg. C group; injected subcutaneously with DNX 0.1mg/kg. D group; injected subcutaneously with TNT 0.1mg/kg. E group; applied DNX 50mg with olive oli, (0.5 or 1c.c.) on the neck. F group; applied TNT 50mg with olive oil, (0.5 or 1c.c.) on the neck. G group; injeced subcutaneously with olive oil 50mg/kg. as the control group. The following items were observed once a week throughout the experiment term of 88 days: body weight, specific gravity of total blood, hemoglobin content, methemoglobin concentration, appearance of Heinz' body, leucocyte counts and hemogramm. After 88 days, animals were killed, and nucleated cells of the bone marrow were counted and pathological changes of organs were observed macro- and microscopically. Results (1) As symptomes of DNX poisoning, anaemia; appearance of methemoglobin and Heinz' bodies; injuries of liver, spleen and kidney were noted. These findings were similar to those of TNT poisoning. (2) DNX showed less effects in peripheral blood picture than TNT, but heavier effects against the bone marrow, liver spleen and kidney. (3) In A and B groups the findings were remarkable in all items examined, but in E and F groups hardly in any items. In C and D groups slight changes of liver were noted microscopic examination.

Journal

  • Sangyo Igaku

    Sangyo Igaku 5 (6), 445-452, 1963

    Japan Society for Occupational Health

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