Effect of S-Adenosylmethionine on Antibiotic Production in Streptomyces griseus and Streptomyces griseoflavus
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- Saito Natsumi
- National Food Research Institute
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- Kurosawa Kazuhiko
- National Food Research Institute
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- Xu Jun
- National Food Research Institute
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- Okamoto Susumu
- National Food Research Institute
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- Ochi Kozo
- National Food Research Institute
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Description
S-Adenosylmethionine caused overproduction of streptomycin (by Streptomyces griseus) and bicozamycin (by Streptomyces griseoflavus) when added to the medium at an appropriate concentration. The enhancement of streptomycin production was accompanied by a 1.35-fold increase in transcript of strR (a pathway-specific positive regulatory gene), and a 1.9-fold increase in activity of streptomycin kinase (an enzyme for streptomycin biosynthesis). These results, together with the previous works dealing with Streptomyces coelicolor (J. Bacteriol. 185, 601–609, 2003) and Streptomyces lividans (J. Bacteriol, 185, 592–600, 2003), implicate the significance of S-adenosylmethionine as an intracellular signal molecule for onset of secondary metabolism in the Streptomyces species.
Journal
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- Actinomycetologica
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Actinomycetologica 17 (2), 47-49, 2003
The Society for Actinomycetes Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679678054528
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- NII Article ID
- 130004487531
- 10012501186
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- NII Book ID
- AN10080091
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- COI
- 1:CAS:528:DC%2BD2cXktVOrsrw%3D
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- ISSN
- 18816371
- 09145818
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- NDL BIB ID
- 6876648
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed