ラット脾臓の実験的鼠癩病変からみた脾臓内微小循環,細胞動態と脾臓各領域の機能

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タイトル別名
  • Intrasplenic Microcirculation, Cellular Movement and Regional Functions in Experimental Leprosy in Rats

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The formation and distribution of metastatic leprotic lesions in the spleen from cutaneous granulomas of leprosy were experimentally investigated with respect to the intrasplenic microcirculation, cell movement and regional function.<br>Seventy-seven Wistar strain male rats were intradermally inoculated with 1×107 of Mycobacterium lepraemurium at the sternal region. Granulomas developed in the subcutis from 8 weeks after inoculation in 53 rats. Splenic lesions having bacilli were observed in 21 of these rats. No splenic lesions were observed in the rats in which no subcutaneous granuloma developed at the site of the inoculation. The splenic leprotic lesions were examined in the hematoxylin-eosin and Ziehl-Neelsen stained sections, and classified into the three types of 1) extracellular free bacillus, 2) single macrophage which phagocytosed bacilli and formed no granuloma, and 3) granuloma which was a compact accumulation of macrophages phagocytosing bacilli.<br>The combined total of the three types of lesions was 543; 327 granulomas, 127 single macrophages and 89 bacilli. Analysis of their localization revealed 58% of the lesions in the periarteriolar lymphocytic sheath (PALS), 8% in the marginal zone (MZ), and 34% in the red pulp (RP). Granulomas were found in 66%, 8% and 26% of these lesions in the PALS, MZ and RP, respectively; macrophages in 50%, 8% and 43% of these in the PALS, MZ, and RP; and extracellular free bacilli in 39%, 10% and 51% of these in the PALS, MZ and RP. No leprotic lesions were present in the follicles.<br>The results suggest that the free macrophages phagocytosing the bacilli and the extracellular free bacilli move to the PALS from the MZ and RP. Thus, Mycobacterium lepraemurium, as a thymus-dependent antigen, provokes granulomatous inflammation mainly in the PALS, although some granulomas develop. in the MZ and RP.

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詳細情報 詳細情報について

  • CRID
    1390282679678083328
  • NII論文ID
    130003441591
  • DOI
    10.3960/jslrt1961.27.263
  • ISSN
    18836801
    03869725
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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