Regulation by A-factor and afsR of Secondary Metabolism and Morphogenesis in Streptomyces.

DOI

この論文をさがす

説明

A-factor (2-isocapryloyl-3R-hydroxymethyl-γ-butyrolactone) is a microbial hormone that functions as a key switch for secondary metabolite formation and cell differentiation in Streptomyces griseus. Genetic and biochemical studies on the A-factor-binding protein have implied that the binding protein plays a role in repressing streptomycin (Sm) production and sporulation while the binding of A-factor to the binding protein releases its repression. The positive A-factor signal is transferred, probably via some additional unknown regulatory proteins, to the strR gene, a putative regulator for Sm biosynthesis. The StrR product, in turn, activates the other Sm production genes.<BR>A global regulatory gene, afsR, of Streptomyces coelicolor A3(2) encodes a 993-amino acid protein that is phosphorylated by a specific phosphokinase present in the same organism. Characterization of AfsR by means of site-directed mutagenesis has revealed that phosphorylated AfsR stimulates globally transcription of antibiotic production genes. It is most likely that the AfsR protein and the AfsR-phosphokinase compose a two-component regulatory system.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390282679678934656
  • NII論文ID
    130004886066
  • DOI
    10.3209/saj.5_119
  • ISSN
    18816371
    09145818
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

問題の指摘

ページトップへ